Journal: Frontiers in Immunology
Article Title: Emerging prospects of mRNA cancer vaccines: mechanisms, formulations, and challenges in cancer immunotherapy
doi: 10.3389/fimmu.2024.1448489
Figure Lengend Snippet: mRNA vaccine for different cancer types.
Article Snippet: NCT03739931 , Advanced solid tumors , In situ vaccine (ISV) with mRNA-2752 (Human OX40L, IL-23, and IL-36γ) , Tumor-associated antigens, with a focus on neoantigens , Intratumoral injections of mRNA-2752 alone and in combination with intravenously administered durvalumab , Intratumoral injection , Phase 1, open-label, multicenter study actively recruiting participants, with Dose Escalation, Dose Confirmation, and Dose Expansion Parts , ModernaTX, Inc..
Techniques: Injection, Control, Wilms Tumor Assay, Immunopeptidomics, Next-Generation Sequencing, In Situ, Transplantation Assay, Retroviral, Transfection, Ex Vivo, Recombinant